Antitrypanosomal sesquiterpene lactones from Saussurea costus
Abstract
In the course of a larger screen of 1800 plant and fungal extracts, the ethyl acetate extract of Saussurea costus roots potently inhibited the growth of Trypanosoma brucei rhodesiense. Subsequent HPLC based activity profiling led to the identification of the sesquiterpene lactones arbusculin B (1), α-cyclocostunolide (2), costunolide (3), and dehydrocostuslactone (4). They were tested for in vitro antitrypanosomal activities and cytotoxicity...
Paper Details
Title
Antitrypanosomal sesquiterpene lactones from Saussurea costus
Published Date
Oct 1, 2011
Journal
Volume
82
Issue
7
Pages
955 - 959
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