Durable Tumor Regression in Genetically Altered Malignant Rhabdoid Tumors by Inhibition of EZH2
Abstract
Malignant rhabdoid tumors (MRTs) and atypical teratoid rhabdoid tumors (AT/RTs) are extremely aggressive pediatric cancers of the brain, kidney, and soft tissues that are highly malignant and particularly lethal due to the lack of an effective treatment. Interestingly, these tumors are typically genetically silent (i.e. do not harbor many DNA aberrations); however, they are characterized by an almost complete penetrance of loss of SMARCB1, a...
Paper Details
Title
Durable Tumor Regression in Genetically Altered Malignant Rhabdoid Tumors by Inhibition of EZH2
Published Date
Sep 1, 2014
Journal
Volume
207
Issue
9
Pages
452 - 453
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