Determining molecular binding sites on human serum albumin by displacement of oleic acid

Volume: 347, Issue: 2, Pages: 297 - 302
Published: Dec 15, 2005
Abstract
An NMR method was developed for determining binding sites of small molecules on human serum albumin (HSA) by competitive displacement of (13)C-labeled oleic acid. This method is based on the observation that in the crystal structure of HSA complexed with oleic acid, two principal drug-binding sites, Sudlow's sites I (warfarin) and II (ibuprofen), are also occupied by fatty acids. In two-dimensional [(1)H,(13)C]heteronuclear single quantum...
Paper Details
Title
Determining molecular binding sites on human serum albumin by displacement of oleic acid
Published Date
Dec 15, 2005
Volume
347
Issue
2
Pages
297 - 302
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