Determining molecular binding sites on human serum albumin by displacement of oleic acid
Abstract
An NMR method was developed for determining binding sites of small molecules on human serum albumin (HSA) by competitive displacement of (13)C-labeled oleic acid. This method is based on the observation that in the crystal structure of HSA complexed with oleic acid, two principal drug-binding sites, Sudlow's sites I (warfarin) and II (ibuprofen), are also occupied by fatty acids. In two-dimensional [(1)H,(13)C]heteronuclear single quantum...
Paper Details
Title
Determining molecular binding sites on human serum albumin by displacement of oleic acid
Published Date
Dec 15, 2005
Journal
Volume
347
Issue
2
Pages
297 - 302
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