Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload
Abstract
Osteoporosis is one of the leading disorders among aged people. Bone loss results from a number of physiological alterations, such as estrogen decline and aging. Meanwhile, iron overload has been recognized as a risk factor for bone loss. Systemic iron homeostasis is fundamentally governed by the hepcidin–ferroportin regulatory axis, where hepcidin is the key regulator. Hepcidin deficiency could induce a few disorders, of which iron overload is...
Paper Details
Title
Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload
Published Date
Jun 1, 2014
Journal
Volume
543
Issue
1
Pages
161 - 165
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