The effects of the 5-HT3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome.

Volume: 17, Issue: 2, Pages: 212 - 221
Published: Apr 1, 2005
Abstract
Serotonin (5-HT) plays an important role in the pathophysiology of irritable bowel syndrome (IBS). Using a-( 11 C)methyl-L-tryptophan-positron emission tomography (PET), it was demonstrated that brain 5-HT synthesis is increased in patients with IBS, in a gender-specific manner. The aims of the study were to evaluate the effects of alosetron on brain 5-HT syn- thesis in patients with IBS. Six male and five female non-constipation-predominant IBS...
Paper Details
Title
The effects of the 5-HT3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome.
Published Date
Apr 1, 2005
Volume
17
Issue
2
Pages
212 - 221
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