Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats

Since the identification of the alternative angiotensin converting enzyme ( ACE )2/Ang‐(1‐7)/Mas receptor axis, renin‐angiotensin system ( RAS ) is a new complex target for a pharmacological intervention. We investigated the expression of RAS components in the heart and kidney during the development of hypertension and its perinatal treatment with losartan in young spontaneously hypertensive rats ( SHR ). Expressions of RAS genes were studied by...