Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies
Abstract
Cisplatin is one of the most widely used and most potent chemotherapy drugs. However, side effects in normal tissues and organs, notably nephrotoxicity in the kidneys, limit the use of cisplatin and related platinum-based therapeutics. Recent research has shed significant new lights on the mechanism of cisplatin nephrotoxicity, especially on the signaling pathways leading to tubular cell death and inflammation. Renoprotective approaches are...
Paper Details
Title
Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies
Published Date
May 1, 2008
Journal
Volume
73
Issue
9
Pages
994 - 1007
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