MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent.

Volume: 39, Issue: 7, Pages: 1388 - 1405
Published: Jul 1, 2007
Abstract
In the last few years it was found that beside genetic aberrations, epigenetic changes also play an important role in tumorigenesis. Acetylation and deacetylation of histones have been found to contribute to a significant extent to epigenetic regulation of gene expression. Analyses of various tumor models and patient samples revealed that the enzyme class of histone deacetylases is associated with many types of cancer and that, for example,...
Paper Details
Title
MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent.
Published Date
Jul 1, 2007
Volume
39
Issue
7
Pages
1388 - 1405
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