Altered caveolin-3 expression disrupts PI(3) kinase signaling leading to death of cultured muscle cells
Abstract
Caveolae and their coat proteins, caveolins, co-ordinate multiple signaling pathways. Caveolin-3 is a muscle-specific caveolin isoform that is deficient in limb girdle muscular dystrophy type 1 C (LGMD1C). Paradoxically, overexpression of this protein also causes muscle degeneration in vivo. We hypothesize that altered membrane expression of caveolin-3 in muscle cells causes a degenerative phenotype by disrupting the co-ordination of signaling...
Paper Details
Title
Altered caveolin-3 expression disrupts PI(3) kinase signaling leading to death of cultured muscle cells
Published Date
Sep 1, 2006
Journal
Volume
312
Issue
15
Pages
2816 - 2825
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History