Slow Internalization of Anti-HER2 Synthetic Affibody Monomer¹¹¹In-DOTA-Z_{HER2:342-pep2}: Implications for Development of Labeled Tracers

Affibody molecules are a novel class of targeting proteins, demonstrating promising results in the molecular imaging of tumor markers. The aim of this study was to investigate the cellular processing of Affibody molecules bound to human epidermal growth-factor-receptor type 2 (HER2). Cellular processing of the synthetic Affibody molecule, DOTA-ZHER2:342-pep2 (KD = 65 pM) labeled with indium-111, was studied both during continuous and interrupted...