Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)

Volume: 23, Issue: 6, Pages: 681 - 691
Published: May 17, 2013
Abstract
Introduction null The benzothiadiazines and high ceiling diuretics (hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide) contain primary sulfamoyl moieties acting as zinc-binding groups in the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). These drugs are widely used clinically and were recently shown to weakly inhibit isoforms CA I and II, but to possess stronger activity...
Paper Details
Title
Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)
Published Date
May 17, 2013
Volume
23
Issue
6
Pages
681 - 691
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