Engineering of Fibroblast Growth Factor: Alteration of Receptor Binding Specificity
Abstract
A five-residue loop structure in basic fibroblast growth factor (FGF-2) which extends from amino acid residue 118 to residue 122 was replaced, by cassette mutagenesis, with the corresponding seven-residue loop structure from the structural homologue acidic fibroblast growth factor (FGF-1) or the corresponding five-residue loop from interleukin-1 beta to give FGF-2LA and FGF-2LI, respectively. The mutants were expressed in Escherichia coli and...
Paper Details
Title
Engineering of Fibroblast Growth Factor: Alteration of Receptor Binding Specificity
Published Date
Jan 1, 1995
Journal
Volume
34
Issue
3
Pages
731 - 736
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