High Insulin Concentrations Repress Insulin Receptor Gene Expression in Calf Hepatocytes Cultured <i>in Vitro</i>
Abstract
The major role of insulin and the insulin receptor (InsR) in the liver is to mediate glucose uptake into hepatocytes to synthesize glycogen and to maintain blood glucose homeostasis. In this study, we investigated the effects of high insulin concentrations on InsR gene expression in calf hepatocytes cultured in vitro. After the cells were cultured for 72 h, insulin was added to the culture solution at final concentrations of 0, 1, 10, 100 or...
Paper Details
Title
High Insulin Concentrations Repress Insulin Receptor Gene Expression in Calf Hepatocytes Cultured <i>in Vitro</i>
Published Date
Jan 1, 2011
Volume
27
Issue
6
Pages
637 - 640
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