IgE and mast cells in allergic disease

Published on May 1, 2012in Nature Medicine36.13
· DOI :10.1038/NM.2755
Stephen J. Galli130
Estimated H-index: 130
(Stanford University),
Mindy Tsai63
Estimated H-index: 63
(Stanford University)
Both mast cells and IgE play crucial parts during the initiation and amplification of the allergic response during asthma, as well as during the tissue remodeling that occurs at the chronic stage. This review discusses how these two players can affect the development of asthma through independent and interdependent functions and the therapeutic implications for treating the clinical symptoms derived from allergic disease.
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