IgE and mast cells in allergic disease

Published on May 1, 2012in Nature Medicine36.13
· DOI :10.1038/NM.2755
Stephen J. Galli130
Estimated H-index: 130
(Stanford University),
Mindy Tsai63
Estimated H-index: 63
(Stanford University)
Sources
Abstract
Both mast cells and IgE play crucial parts during the initiation and amplification of the allergic response during asthma, as well as during the tissue remodeling that occurs at the chronic stage. This review discusses how these two players can affect the development of asthma through independent and interdependent functions and the therapeutic implications for treating the clinical symptoms derived from allergic disease.
📖 Papers frequently viewed together
200842.78Nature
1,182 Citations
821 Citations
520 Citations
References170
Newest
#1Ruder Novak (University of Zagreb)H-Index: 3
#2Sanja Dabelić (University of Zagreb)H-Index: 10
Last. Jerka Dumić (University of Zagreb)H-Index: 13
view all 3 authors...
Abstract Background Galectins have been identified as modulators of many monocyte/macrophage functions. In the response to a wide range of environmental cues macrophages may exhibit different biochemical and biological characteristics, but two main subtypes, classically (M1) and alternatively (M2) activated macrophages have been recognized. To contribute to elucidation of role and regulation of galectin-1 and galectin-3 in differently activated macrophages we explored their expression profiles i...
71 CitationsSource
#1Davinder Kaur (University of Leicester)H-Index: 20
#2Camille Doe (University of Leicester)H-Index: 11
Last. Christopher E. Brightling (University of Leicester)H-Index: 110
view all 7 authors...
Background The mast cell localization to airway smooth muscle (ASM) bundle in asthma is important in the development of disordered airway physiology. Thymic stromal lymphopoietin (TSLP) is expressed by airway structural cells. Whether it has a role in the crosstalk between these cells is uncertain. We sought to define TSLP expression in bronchial tissue across the spectrum of asthma severity and to investigate the TSLP and TSLP receptor (TSLPR) expression and function by primary ASM and mast cel...
46 CitationsSource
Last year's "Advances in pediatric asthma" concluded with the following statement: "Perhaps new directions in personalized medicine and improved health care access and communication will help maintain steady progress in alleviating the burden of this disease in children, especially young children." This year's summary will focus on recent advances in pediatric asthma that show significant accomplishments in reducing asthma morbidity and mortality over the last 10 years and discuss some pathways ...
16 CitationsSource
Atopic dermatitis (AD) is a complex disease that affects up to 20% of children and impacts the quality of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Filaggrin (FLG) is synthesized as a large precursor, profilaggrin, and is expressed in the upper layers of the epidermis. FLG plays a critical role in the epidermal barrier, and FLG mutations cau...
55 CitationsSource
#1Barbara Platzer (Harvard University)H-Index: 16
#2Floortje Ruiter (Harvard University)H-Index: 2
Last. Edda Fiebiger (Harvard University)H-Index: 38
view all 4 authors...
Abstract Soluble isoforms of three human IgE Fc receptors, namely FcɛRI, FcɛRII, and galectin-3, can be found in serum. These soluble IgE receptors are a diverse family of proteins unified by the characteristic of interacting with IgE in the extracellular matrix. A truncated form of the alpha-chain of FcɛRI, the high affinity IgE receptor, has recently been described as a soluble isoform (sFcɛRI). Multiple soluble isoforms of CD23 (sCD23), the low affinity IgE receptor also known as FcɛRII, are ...
37 CitationsSource
#1Stanley J. Szefler (University of Colorado Denver)H-Index: 116
#2Azzeddine Dakhama (University of Colorado Denver)H-Index: 6
Although national asthma guidelines help organize standards for asthma care, current asthma management is still primarily symptom based. Recent reports provide insights on how to improve asthma management through steps to better understand the natural history of asthma, individualize asthma care, reduce asthma exacerbations, manage inner city asthma, and some potential new ways to use available medications to improve asthma control. Despite many significant gains in managing asthma, we must now ...
9 CitationsSource
#1Adeline Porcherie (Pasteur Institute)H-Index: 9
#2Cedric Mathieu (Pasteur Institute)H-Index: 4
Last. Salaheddine Mécheri (Pasteur Institute)H-Index: 25
view all 14 authors...
The role of the IgE–FceRI complex in malaria severity in Plasmodium falciparum–hosting patients is unknown. We demonstrate that mice genetically deficient for the high-affinity receptor for IgE (FceRIα-KO) or for IgE (IgE-KO) are less susceptible to experimental cerebral malaria (ECM) after infection with Plasmodium berghei (PbANKA). Mast cells and basophils, which are the classical IgE-expressing effector cells, are not involved in disease as mast cell–deficient and basophil-depleted mice devel...
71 CitationsSource
#1Riccardo Sibilano (University of Udine)H-Index: 16
#2Giorgia Gri (University of Udine)H-Index: 28
Last. Carlo Pucillo (University of Udine)H-Index: 36
view all 8 authors...
Tregs play a central role in modulating Fc?RI-dependent MC effector functions in the course of the allergic response. Cellular interaction depends on the constitutive expression of OX40 on Tregs and the OX40L counterpart on MCs. Study of OX40L signaling on MCs is hampered by the need of a highly purified molecule, which triggers OX40L specifically. We now report that sOX40 mimics the physiological activity of Treg interaction by binding to activated MCs. When treated with sOX40, activated MCs sh...
8 CitationsSource
#1Naresh Singh Redhu (UM: University of Manitoba)H-Index: 17
#2Ali Saleh (UM: University of Manitoba)H-Index: 10
Last. Abdelilah S. Gounni (UM: University of Manitoba)H-Index: 31
view all 6 authors...
33 CitationsSource
#1Atsushi Otsuka (Kyoto University)H-Index: 31
#2Masato KuboH-Index: 70
Last. Kenji Kabashima (Kyoto University)H-Index: 80
view all 12 authors...
The role of mast cells (MCs) in contact hypersensitivity (CHS) remains controversial. This is due in part to the use of the MC-deficient Kit W/Wv mouse model, since Kit W/Wv mice congenitally lack other types of cells as a result of a point mutation in c-kit. A recent study indicated that the intronic enhancer (IE) for Il4 gene transcription is essential for MCs but not in other cell types. The aim of this study is to re-evaluate the roles of MCs in CHS using mice in which MCs can be conditional...
112 CitationsSource
Cited By1024
Newest
#1Eric J. Wigton (UCSF: University of California, San Francisco)H-Index: 4
#2Yohei Mikami (NIH: National Institutes of Health)H-Index: 25
Last. Daisuke Kitamura (Ridai: Tokyo University of Science)H-Index: 49
view all 15 authors...
MicroRNAs (miRNAs, miRs) regulate cell fate decisions by post-transcriptionally tuning networks of mRNA targets. We used miRNA-directed pathway discovery to reveal a regulatory circuit that influences Ig class switch recombination (CSR). We developed a system to deplete mature, activated B cells of miRNAs, and performed a rescue screen that identified the miR-221/222 family as a positive regulator of CSR. Endogenous miR-221/222 regulated B cell CSR to IgE and IgG1 in vitro, and miR-221/222-defic...
Source
#1Huan Li (ZJSU: Zhejiang Gongshang University)H-Index: 2
#2Jiacheng Gan (ZJSU: Zhejiang Gongshang University)
Last. Yanbo Wang (ZJSU: Zhejiang Gongshang University)H-Index: 11
view all 5 authors...
Abstract null null Biogenic amines (BAs) are not only well-known indicators for food freshness but can cause serious harm to the body after excessive consumption, which makes the determination of its content in food of great significance. In this work, a simple and convenient method for colorimetric detection of BAs was developed based on the sensitivity of the polymerization of dopamine to the presence of BAs on the surface of gold nanoparticles (AuNPs). Taking histamine as a representative, th...
Source
#1Pavel Kolkhir (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 13
#2Daniel Elieh-Ali-Komi (Urmia University of Medical Sciences)
Last. Marcus Maurer (Fraunhofer Society)H-Index: 83
view all 5 authors...
Mast cells have crucial roles in allergic and other inflammatory diseases. Preclinical approaches provide circumstantial evidence for mast cell involvement in many diseases, but these studies have major limitations — for example, there is still a lack of suitable mouse models for some mast cell-driven diseases such as urticaria. Some approaches for studying mast cells are invasive or can induce severe reactions, and very few mediators or receptors are specific for mast cells. Recently, several d...
Source
#1Meesum Syed (MSU: Michigan State University)H-Index: 2
#2Ananth K. Kammala (MSU: Michigan State University)H-Index: 3
Last. Hariharan Subramanian (MSU: Michigan State University)H-Index: 14
view all 5 authors...
Abstract null null MAS related G-protein coupled receptor X2 (MRGPRX2) is a G-protein coupled receptor (GPCR) expressed in human mast cells that has been implicated to play an important role in causing pseudo-allergic reactions as well as exacerbating inflammation during asthma and other allergic diseases. Lactic acid, a byproduct of glucose metabolism, is abundantly present in inflamed tissues and has been shown to regulate functions of several immune cells. Because the endogenous ligands for M...
Source
#1Kyung-Ah Cho (Ewha Womans University)H-Index: 15
#2Da-Won Choi (Ewha Womans University)
Last. So-Youn Woo (Ewha Womans University)H-Index: 25
view all 5 authors...
Source
#5R.Z Chen (SEU: Southeast University)
Background and Aim: Diarrhea, abdominal pain, and bloating are frequent in irritable bowel syndrome (IBS)-like disorders, although little is known about their intestinal ultrastructural alterations. The aim of the present study was to study duodenal biopsies from IBS-like patients to find ultrastructural alterations. Materials and Methods: Study design: descriptive comparative pilot study. Thirty outpatients (9 male and 21 female; median age 37.7 years; range, 20 to 65 years) complaining of IBS-...
Source
#1Yu-Wen Yeh (PolyU: Hong Kong Polytechnic University)
#2Arka Sen Chaudhuri (PolyU: Hong Kong Polytechnic University)
Last. Zou Xiang (PolyU: Hong Kong Polytechnic University)H-Index: 26
view all 6 authors...
Background: It is well documented that laboratory mice bred and maintained in ultra-hygienic specific pathogen-free (SPF) barriers display reduced richness and complexity of microbiota compared with wild mice. The laboratory mice profoundly lack lung parenchymal mast cells. Hence, we aimed to investigate the lung distribution of mast cells in free-living wild mice. Methods: Wild house mice were trapped in South-Eastern Norway and Hemtabad, West Bengal, India. C57BL/6 laboratory mice were bred in...
Source
#1Suhyun LimH-Index: 1
Last. Bonglee KimH-Index: 21
view all 8 authors...
More than 500 million people suffer from allergic rhinitis (AR) in the world. Current treatments include oral antihistamines and intranasal corticosteroids; however, they often cause side effects and are unsuitable for long-term exposure. Natural products could work as a feasible alternative, and this study aimed to review the efficacies and mechanisms of natural substances in AR therapies by examining previous literature. Fifty-seven studies were collected and classified into plants, fungi, and...
Source
Last. Qi Wang (Beijing University of Chinese Medicine)H-Index: 10
view all 8 authors...
Allergic asthma is a stubborn chronic inflammatory disease, and is considered a co-result of many kinds of immune cells, especially mast cells, eosinophils and T lymphocytes. At present, the treatment methods of allergic asthma are limited and the side effects are obvious. Traditional Chinese medicine has been used to treat diseases for thousands of years in China. One such example is the treatment of allergic asthma, which take the characteristics of less adverse reactions and obvious curative ...
Source
Last. Se-Young ChoungH-Index: 20
view all 3 authors...
The incidence of atopic dermatitis (AD), a disease characterized by an abnormal immune balance and skin barrier function, has increased rapidly in developed countries. This study investigated the anti-atopic effect of Lithospermum erythrorhizon (LE) using NC/Nga mice induced by 2,4-dinitrochlorobenzene. LE reduced AD clinical symptoms, including inflammatory cell infiltration, epidermal thickness, ear thickness, and scratching behavior, in the mice. Additionally, LE reduced serum IgE and histami...
Source