A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells
Abstract
How adherent and contractile systems coordinate to promote cell shape changes is unclear. Here, we define a counterbalanced adhesion/contraction model for cell shape control. Live-cell microscopy data showed a crucial role for a contractile meshwork at the top of the cell, which is composed of actin arcs and myosin IIA filaments. The contractile actin meshwork is organized like muscle sarcomeres, with repeating myosin II filaments separated by...
Paper Details
Title
A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells
Published Date
Apr 7, 2014
Journal
Volume
205
Issue
1
Pages
83 - 96
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