Regularization design in penalized maximum-likelihood image reconstruction for lesion detection in 3D PET

Detecting cancerous lesions is a major clinical application in emission tomography. In previous work, we have studied penalized maximum-likelihood (PML) image reconstruction for the detection task and proposed a method to design a shift-invariant quadratic penalty function to maximize detectability of a lesion at a known location in a two dimensional image. Here we extend the regularization design to maximize detectability of lesions at unknown...