Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard
Abstract
Nitrogen mustard is a vesicant that causes damage to the respiratory tract. In these studies, we characterized the acute effects of nitrogen mustard on lung structure, inflammatory mediator expression, and pulmonary function, with the goal of identifying mediators potentially involved in toxicity. Treatment of rats (male Wistar, 200–225 g) with nitrogen mustard (mechlorethamine hydrochloride, i.t., 0.25 mg/kg) resulted in marked histological...
Paper Details
Title
Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard
Published Date
Jan 1, 2011
Volume
250
Issue
1
Pages
10 - 18
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