Genetic variation in GABRA2 moderates peer influence on externalizing behavior in adolescents

Background Genetic predisposition and environmental influences are both important factors in the development of problematic behavior leading to substance use in adolescence. Involvement with delinquent peers also strongly predicts adolescent externalizing behavior. Several lines of evidence support a role of GABRA 2 on externalizing behavior related to disinhibition. However, whether this genetic association is influenced by the environment such...