Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.
Abstract
The effect of genetic mutation on phenotype is of significant interest in genetics. The type of genetic mutation that causes a single amino acid substitution (AAS) in a protein sequence is called a non-synonymous single nucleotide polymorphism (nsSNP). An nsSNP could potentially affect the function of the protein, subsequently altering the carrier's phenotype. This protocol describes the use of the 'Sorting Tolerant From Intolerant' (SIFT)...
Paper Details
Title
Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.
Published Date
Jun 25, 2009
Journal
Volume
4
Issue
7
Pages
1073 - 1081
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