Unmasking Translucent Protein Particles by Improved Micro-Flow Imaging™ Algorithms

Micro-flow imaging (MFI™) is an increasingly important technique for the characterization of subvisible particles during the development of biopharmaceutical products. Protein particles are highly variable in size, appearance, and translucency posing challenges to optical detection techniques. We have developed a set of standard statistical tests applicable for routine evaluation of MFI™ particle dataset quality. The tests evaluate the spatial...