Inhibition of Vav3 could reverse the drug resistance of gastric cancer cells by downregulating JNK signaling pathway
Abstract
This study aims to investigate the effect and mechanism of Vav3 on the multidrug resistance of gastric cancer. Fluorescence quantitative RT-PCR and western blot assay were used to detect Vav3 and drug resistance genes in gastric cancer tissues as well as gastric cell lines such as SGC7901, SGC7901/adriamycin (ADR) and GES-1. Besides, Vav3-specific small interfering RNA (Vav3-siRNA) was applied to inhibit Vav3 in SGC7901/ADR, and SRB assay was...
Paper Details
Title
Inhibition of Vav3 could reverse the drug resistance of gastric cancer cells by downregulating JNK signaling pathway
Published Date
Nov 28, 2014
Journal
Volume
21
Issue
12
Pages
526 - 531
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