The pharmacokinetics of methadone and its metabolites in neonates, infants, and children

Volume: 24, Issue: 6, Pages: 591 - 601
Published: Jun 1, 2014
Abstract
Background The lack of methadone pharmacokinetic data in children and neonates restrains dosing to achieve the target concentration in these populations. A minimum effective analgesic concentration of methadone in opioid naive adults is 0.058 mg.L−1, while no withdrawal symptoms were observed in neonates suffering opioid withdrawal if plasma concentrations of methadone were above 0.06 mg.L−1. The racemate of methadone which is commonly used in...
Paper Details
Title
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children
Published Date
Jun 1, 2014
Volume
24
Issue
6
Pages
591 - 601
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