The relationship between dNTP pool levels and mutagenesis in an Escherichia coli NDP kinase mutant

Loss of nucleoside diphosphate kinase (Ndk) function in Escherichia coli results in an increased frequency of spontaneous mutation and an imbalance in dNTP pool levels. It is presumed that the imbalance in dNTP pool levels is responsible for the mutator phenotype of an E. coli ndk mutant. A human homologue of Ndk and potential suppressor of tumor metastasis, nm23-H2 , can complement the mutagenic phenotype of an E. coli ndk mutant. Here, we show...