Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease
Abstract
Immunizing transgenic PDAPP mice, which overexpress mutant APP and develop beta-amyloid deposition resembling plaques in Alzheimer's disease (AD), results in a decrease of amyloid burden when compared with non-treated transgenic animals. Immunization with amyloid-beta peptide has been initiated in a randomised pilot study in AD. Yet a minority of patients developed a neurological complication consistent with meningoencephalitis and one patient...
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Paper Details
Title
Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease
DOI
Published Date
Jan 1, 2004
Journal
Volume
14
Issue
1
Pages
11 - 20
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