The clinical benefit of cardiac resynchronization therapy for narrow QRS compared to broad QRS complex patients.

Published on Mar 15, 2015in International Journal of Cardiology3.229
· DOI :10.1016/J.IJCARD.2015.01.042
Lok Bin Yap2
Estimated H-index: 2
(NIH: National Institutes of Health),
Faisal Qadir1
Estimated H-index: 1
(NIH: National Institutes of Health)
+ 13 AuthorsRazali Omar15
Estimated H-index: 15
(NIH: National Institutes of Health)
Sources
Abstract
📖 Papers frequently viewed together
1 Citations
14 Citations
1 Citations
References10
Newest
#1Frank RuschitzkaH-Index: 89
#2William T. AbrahamH-Index: 123
Last. Johannes Holzmeister (UZH: University of Zurich)H-Index: 19
view all 13 authors...
BACKGROUND Cardiac-resynchronization therapy (CRT) reduces morbidity and mortality in chronic systolic heart failure with a wide QRS complex. Mechanical dyssynchrony also occurs in patients with a narrow QRS complex, which suggests the potential usefulness of CRT in such patients. METHODS We conducted a randomized trial involving 115 centers to evaluate the effect of CRT in patients with New York Heart Association class III or IV heart failure, a left ventricular ejection fraction of 35% or less...
523 CitationsSource
#1Bernard Thibault (MHI: Montreal Heart Institute)H-Index: 52
#2François HarelH-Index: 22
Last. Paul KhairyH-Index: 70
view all 16 authors...
Background— Although the benefits of cardiac resynchronization therapy are well established in selected patients with heart failure and a prolonged QRS duration, salutary effects in patients with narrow QRS complexes remain to be demonstrated. Methods and Results— The Evaluation of Resynchronization Therapy for Heart Failure (LESSER-EARTH) trial is a randomized, double-blind, 12-center study that was designed to compare the effects of active and inactive cardiac resynchronization therapy in pati...
106 CitationsSource
#4John P. DiMarcoH-Index: 50
#5Sandra B. Dunbar (American Association for Thoracic Surgery)H-Index: 6
Last. Mark S. LinkH-Index: 81
view all 17 authors...
Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons Andrew E. Epstein, MD, FACC, FAHA, FHRS, Chair ; John P. DiMarco, MD, PhD, FACC, FHRS; Kenneth A. Ellenbogen. MD, FACC, FAHA, FHRS; N.A. Mark Estes III, MD, FACC, FAHA, FHRS; Roger A.
1,278 CitationsSource
#4John P. DiMarco (American Association for Thoracic Surgery)H-Index: 52
Developed in Collaboration With the American Association for Thoracic Surgery, Heart Failure Society of America, and Society of Thoracic Surgeons
268 CitationsSource
#1Tim Donahue (Ochsner Medical Center)H-Index: 2
#3Angel R. Leon (Emory University)H-Index: 34
Last. Esteem-Crt InvestigatorsH-Index: 2
view all 6 authors...
Previous studies suggest that CRT may benefit narrow QRS patients with mechanical dyssynchrony (MD). We conducted an acute and chronic study, evaluating the response of heart failure patients with a narrow QRS to cardiac resynchronization therapy (CRT). ESTEEM-CRT was a multi-center, single-arm, feasibility study that evaluated ICD-indicated, medically-optimized patients with EF ≤ 35%, NYHA class III heart failure, QRS duration <120 ms, and MD as defined by the standard deviation of time to peak...
20 CitationsSource
#1Paul W X Foley (Queen Elizabeth Hospital Birmingham)H-Index: 21
#2Kiran PatelH-Index: 24
Last. Francisco LeyvaH-Index: 21
view all 8 authors...
Objectives To evaluate the clinical response to cardiac resynchronisation therapy (CRT) in patients with heart failure and a normal QRS duration ( Setting Single centre. Patients 60 patients with heart failure and a normal QRS duration receiving optimal pharmacological treatment (OPT). Interventions Patients were randomly assigned to CRT (n=29) or to a control group (OPT, n=31). Cardiovascular magnetic resonance was used in order to avoid scar at the site of left ventricular (LV) lead deployment...
44 CitationsSource
#1R. J. Van Bommel (LUMC: Leiden University Medical Center)H-Index: 2
#2John GorcsanH-Index: 7
Last. Bart GerritseH-Index: 21
view all 13 authors...
INTRODUCTION: Current guidelines recommend cardiac resynchronisation therapy (CRT) in patients with severe symptomatic heart failure, depressed left ventricular (LV) systolic function and a wide QRS complex (>or=120 ms). However, patients with heart failure having a narrow QRS complex might also benefit from CRT. DESIGN SETTING PATIENTS INTERVENTIONS: During the Predictors of Response to Cardiac Resynchronisation Therapy (PROSPECT) trial, 41 patients were enrolled in a 'narrow' QRS sub-study. Th...
34 CitationsSource
#1John F. Beshai (U of C: University of Chicago)H-Index: 18
#2Richard A. Grimm (Cleveland Clinic)H-Index: 61
Last. Patrick J. Tchou (Cleveland Clinic)H-Index: 64
view all 8 authors...
Background Indications for cardiac-resynchronization therapy (CRT) in patients with heart failure include a prolonged QRS interval (≥120 msec), in addition to other functional criteria. Some patients with narrow QRS complexes have echocardiographic evidence of left ventricular mechanical dyssynchrony and may also benefit from CRT. Methods We enrolled 172 patients who had a standard indication for an implantable cardioverter–defibrillator. Patients received the CRT device and were randomly assign...
672 CitationsSource
#1Gabe B. Bleeker (LUMC: Leiden University Medical Center)H-Index: 52
#2Eduard R. Holman (LUMC: Leiden University Medical Center)H-Index: 61
Last. Jeroen J. Bax (LUMC: Leiden University Medical Center)H-Index: 164
view all 7 authors...
Objectives The purpose of this study was to evaluate the effects of cardiac resynchronization therapy (CRT) in heart failure patients with narrow QRS complex ( Background Cardiac resynchronization therapy is beneficial in selected heart failure patients with wide QRS complex (≥120 ms). Patients with narrow QRS complex are currently not eligible for CRT, and the potential effects of CRT are not well studied. Methods Thirty-three consecutive patients with narrow QRS complex and 33 consecutive pati...
240 CitationsSource
#1Cheuk-Man Yu (CUHK: The Chinese University of Hong Kong)H-Index: 81
#2Yat-Sun Chan (CUHK: The Chinese University of Hong Kong)H-Index: 12
Last. Jeffrey Wing-Hong Fung (CUHK: The Chinese University of Hong Kong)H-Index: 33
view all 10 authors...
Objectives This study was designed to evaluate the role of cardiac resynchronization therapy (CRT) in heart failure (HF) patients with narrow QRS complexes ( Background Cardiac resynchronization therapy is currently recommended to advanced HF patients with prolonged QRS duration. Echocardiographic assessment of systolic mechanical asynchrony has been proven useful to predict a favorable response after CRT. Methods A total of 102 HF patients with New York Heart Association (NYHA) functional class...
247 CitationsSource
Cited By1
Newest
#1Arun Aneja (Wake Forest Baptist Medical Center)H-Index: 1
#2Jimmy J. Jiang (U of C: University of Chicago)H-Index: 11
Last. Rex C. Haydon (U of C: University of Chicago)H-Index: 71
view all 8 authors...
Background: We are not aware of any previous studies that have compared the rate of venous thromboembolic events in patients who underwent prophylactic intramedullary nailing because of an impending fracture with the rate in patients who underwent intramedullary nailing after a pathological fracture. The objective of the present study was to determine if the rate of venous thromboembolic events varies between patients who are managed with prophylactic fixation and those who are managed with fixa...
8 CitationsSource