Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

Adhesion assembly is needed for cell migration. Horwitz and colleagues report that new adhesions assemble in the lamellipodium in a manner that is independent of myosin II but requires actin polymerization. Using two-colour imaging and high resolution TIRF microscopy, we investigated the assembly and maturation of nascent adhesions in migrating cells. We show that nascent adhesions assemble and are stable within the lamellipodium. The assembly...