Neuropeptide Y modulates effects of bradykinin and prostaglandin E₂on trigeminal nociceptors via activation of the Y₁and Y₂receptors

Background and Purpose: Although previous studies have demonstrated that neuropeptide Y (NPY) modulates nociceptors, the relative contributions of the Y 1 and Y 2 receptors are unknown. Therefore, we evaluated the effect of Y 1 and Y 2 receptor activation on nociceptors stimulated by bradykinin (BK) and prostaglandin E 2 (PGE 2 ). Experimental approach: Combined immunohistochemistry (IHC) with in situ hybridization (ISH) demonstrated that Y 1 ‐...