MUC1: a multifaceted oncoprotein with a key role in cancer progression

•MUC1 promotes growth, metastasis, and resistance to drugs in cancer. •In tumors, the cytoplasmic tail of MUC1 acts as an oncogenic signaling molecule. •MUC1 regulates gene expression at transcriptional and post-transcriptional levels. •MUC1 is critical for maintaining ‘stemness’ in embryonic and cancer stem cells. The transmembrane glycoprotein Mucin 1 (MUC1) is aberrantly glycosylated and overexpressed in a variety of epithelial cancers, and...