Selective Regulation of Somatostatin Receptor Subtype Signaling: Evidence for Constitutive Receptor Activation
Abstract
Anterior pituitary hormone secretion is under tonic suppression by hypothalamic somatostatin signaling through somatostatin receptor subtypes (SSTs). Because some hormonal axes are known to be abnormally regulated by ligand-independent constitutively active G protein-coupled receptors, we tested pituitary SSTs for selective constitutive signaling. We therefore differentially silenced endogenous SST2, SST3, and SST5 in somatostatin-sensitive...
Paper Details
Title
Selective Regulation of Somatostatin Receptor Subtype Signaling: Evidence for Constitutive Receptor Activation
Published Date
Oct 1, 2007
Journal
Volume
21
Issue
10
Pages
2565 - 2578
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