Chitosan-based dressings loaded with neurotensin—an efficient strategy to improve early diabetic wound healing
Abstract
One important complication of diabetes mellitus is chronic, non-healing diabetic foot ulcers (DFUs). This study aims to develop and use dressings based on chitosan derivatives for the sustained delivery of neurotensin (NT), a neuropeptide that acts as an inflammatory modulator in wound healing. Three different derivatives, namely N-carboxymethyl chitosan, 5-methyl pyrrolidinone chitosan (MPC) and N-succinyl chitosan, are presented as potential...
Paper Details
Title
Chitosan-based dressings loaded with neurotensin—an efficient strategy to improve early diabetic wound healing
Published Date
Feb 1, 2014
Journal
Volume
10
Issue
2
Pages
843 - 857
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