Fabrication of a model continuously graded co-electrospun mesh for regeneration of the ligament–bone interface

Current scaffolds for the regeneration of anterior cruciate ligament injuries are unable to capture intricate mechanical and chemical gradients present in the natural ligament–bone interface. As a result, stress concentrations can develop at the scaffold–bone interface, leading to poor osseointegration. Hence, scaffolds that possess appropriate mechano-chemical gradients would help establish normal loading properties at the interface, while...