N-Glycosylation Regulates ADAM8 Processing and Activation
Volume: 289, Issue: 48, Pages: 33676 - 33688
Published: Nov 1, 2014
Abstract
The transmembrane ADAM8 (A Disintegrin And Metalloproteinase 8) protein is abundantly expressed in human breast tumors and derived metastases compared with normal breast tissue, and plays critical roles in aggressive Triple-Negative breast cancers (TNBCs). During ADAM8 maturation, the inactive proform dimerizes or multimerizes and autocatalytically removes the prodomain leading to the formation of the active, processed form. ADAM8 is a...
Paper Details
Title
N-Glycosylation Regulates ADAM8 Processing and Activation
Published Date
Nov 1, 2014
Volume
289
Issue
48
Pages
33676 - 33688
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