A Rabbit Dry Eye Model Induced by Topical Medication of a Preservative Benzalkonium Chloride

To establish a rabbit dry eye model with topical medication of the ocular preparation preservative benzalkonium chloride (BAC).Sixteen white rabbits were used. One eye of each rabbit was chosen randomly for topical administration of 0.1% BAC twice daily for 14 days. The other untreated eyes served as controls. Schirmer test, fluorescein, and rose bengal staining were performed before and after BAC treatment on days 3, 5, 7, and 14. Conjunctiva...