The constitutively active Ah receptor (CA-AhR) mouse as a model for dioxin exposure – Effects in reproductive organs
Abstract
The dioxin/aryl hydrocarbon receptor (AhR) mediates most toxic effects of dioxins. In utero/lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) impairs fetal/neonatal development and the developing male reproductive tract are among the most sensitive tissues. TCDD causes antiestrogenic responses in rodent mammary gland and uterus and in human breast cancer cell lines in the presence of estrogen. Also, more recently an...
Paper Details
Title
The constitutively active Ah receptor (CA-AhR) mouse as a model for dioxin exposure – Effects in reproductive organs
Published Date
Dec 1, 2011
Journal
Volume
85
Issue
11
Pages
1701 - 1706
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