Temperature induced denaturation of collagen in acidic solution

The denaturation of collagen solution in acetic acid has been investigated by using ultra‐sensitive differential scanning calorimetry (US‐DSC), circular dichroism (CD), and laser light scattering (LLS). US‐DSC measurements reveal that the collagen exhibits a bimodal transition, i.e., there exists a shoulder transition before the major transition. Such a shoulder transition can recover from a cooling when the collagen is heated to a temperature...