Functional hyaluronic acid hydrogels prepared by a novel method

In this study, a novel simple method was developed to prepare functional hyaluronic acid (HA) hydrogels simultaneously containing hydrazone and disulfide bonds in their crossbridges. The HA hydrogels were formed by directly reacting 2,5-hexanedione and 3,3′-dithiodipropionate hydrazide-modified HA, and were characterized by FT–IR, SEM, TGA and mechanical tests. The results showed that the formation of HA hydrogels was a result of the reaction...