New insights into the spatiotemporal localization of prothrombinase in vivo
Abstract
The membrane-dependent interaction of factor Xa (FXa) with factor Va (FVa) forms prothrombinase and drives thrombin formation essential for hemostasis. Activated platelets are considered to provide the primary biological surface to support prothrombinase function. However, the question of how other cell types may cooperate within the biological milieu to affect hemostatic plug formation remains unaddressed. We used confocal fluorescence...
Paper Details
Title
New insights into the spatiotemporal localization of prothrombinase in vivo
Published Date
Sep 11, 2014
Journal
Volume
124
Issue
11
Pages
1705 - 1714
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