Single-nucleotide polymorphism (c.309T>G) in the MDM2 gene and lung cancer risk
Abstract
Murine double minute 2 (MDM2) is a negative regulator of p53. A single‑nucleotide polymorphism (SNP) (rs2279744: c.309T>G) in the promoter region of the MDM2 gene has been shown to result in higher levels of MDM2 RNA and protein. Regarding the contribution of c.309T>G in the MDM2 gene to the lung cancer risk, previous studies are conflicting. In order to evaluate the association between c.309T>G and the lung cancer risk, a case‑control study was...
Paper Details
Title
Single-nucleotide polymorphism (c.309T>G) in the MDM2 gene and lung cancer risk
Published Date
Jun 26, 2014
Journal
Volume
2
Issue
5
Pages
719 - 724
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