The tumor microenvironment and its contribution to tumor evolution toward metastasis

Volume: 130, Issue: 6, Pages: 1091 - 1103
Published: Nov 6, 2008
Abstract
Cancer cells acquire cell-autonomous capacities to undergo limitless proliferation and survival through the activation of oncogenes and inactivation of tumor suppressor genes. Nevertheless, the formation of a clinically relevant tumor requires support from the surrounding normal stroma, also referred to as the tumor microenvironment. Carcinoma-associated fibroblasts, leukocytes, bone marrow-derived cells, blood and lymphatic vascular endothelial...
Paper Details
Title
The tumor microenvironment and its contribution to tumor evolution toward metastasis
Published Date
Nov 6, 2008
Volume
130
Issue
6
Pages
1091 - 1103
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