Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies
Abstract
Insulin-like growth factors (IGFs) are essential for growth and survival that suppress apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in various cancers. The IGFs actions are mediated through the IGF-1 receptor that is involved in cell transformation induced by tumour. These effects depend on the bioavailability of IGFs, which is regulated by IGF binding proteins (IGFBPs). We describe here the role of the...
Paper Details
Title
Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies
Published Date
Jan 1, 2015
Volume
2015
Pages
1 - 24
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