Animal models of HLA-B27-associated diseases: new outcomes
Abstract
The HLA-B27 molecule is strongly associated with the spondyloarthropathies, a group of chronic inflammatory diseases, affecting the skeleton, the bowel and the skin. This association has been largely studied, but mechanisms of pathology remain unclear. The HLA-B27 transgenic rats develop a spontaneous disease that strikingly resembles human spondyloarthropathies, dependent of bacterial flora and implicating the immune system. The presence of...
Paper Details
Title
Animal models of HLA-B27-associated diseases: new outcomes
Published Date
Mar 1, 2006
Journal
Volume
73
Issue
2
Pages
132 - 138
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