Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death
Abstract
Purines such as adenosine, inosine, and hypoxanthine are known to have potent antiinflammatory effects. These effects generally are believed to be mediated by cell surface adenosine receptors. Here we provide evidence that purines protect against oxidant-induced cell injury by inhibiting the activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP). Upon binding to broken DNA, PARP cleaves NAD+ into nicotinamide and ADP-ribose and...
Paper Details
Title
Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death
Published Date
Jan 1, 2001
Journal
Volume
15
Issue
1
Pages
99 - 107
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