Functional imaging for head and neck cancer

Published on Oct 1, 2010in Lancet Oncology33.752
· DOI :10.1016/S1470-2045(10)70169-8
Robin Prestwich28
Estimated H-index: 28
,
Andrew Scarsbrook29
Estimated H-index: 29
+ 1 AuthorsMehmet Sen18
Estimated H-index: 18
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Abstract
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111 Citations
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#1Johan Bussink (Radboud University Nijmegen Medical Centre)H-Index: 33
#2Carla M.L. van Herpen (Radboud University Nijmegen Medical Centre)H-Index: 19
Last. Wim J.G. Oyen (Radboud University Nijmegen Medical Centre)H-Index: 110
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Summary Preferred treatment strategies for advanced-stage squamous cell carcinoma of the head and neck have shifted from surgery to organ-preservation approaches such as radiotherapy, which can be combined with chemotherapy or giving of biologically modifying molecules. Preclinical and clinical researchers aim to customise these treatments on the basis of biological tumour characteristics, including tumour cell proliferation, hypoxia, and apoptosis—important resistance mechanisms for cytotoxic a...
111 CitationsSource
#1June Corry (University of Melbourne)H-Index: 47
#2Lester J. Peters (University of Melbourne)H-Index: 74
Last. Danny Rischin (University of Melbourne)H-Index: 69
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Summary The intensity of contemporary treatment for locally advanced head and neck cancer is at the upper limit of human tolerance of acute toxicities. While impressive gains in locoregional control have been achieved, improvements in overall survival have been more modest. We hypothesise that unrecognised sequelae of highly toxic contemporary treatments substantially contribute to patient mortality. This possibility provides motivation to investigate reducing treatment intensity in selected pat...
80 CitationsSource
Dynamic nuclear polarization of (13)C-labeled cell substrates has been shown to massively increase their sensitivity to detection in NMR experiments. The sensitivity gain is sufficiently large that if these polarized molecules are injected intravenously, their spatial distribution and subsequent conversion into other cell metabolites can be imaged. We have used this method to image the conversion of fumarate to malate in a murine lymphoma tumor in vivo after i.v. injection of hyperpolarized [1,4...
281 CitationsSource
#1Piet Dirix (Katholieke Universiteit Leuven)H-Index: 27
#2Vincent VandecaveyeH-Index: 35
Last. Sandra NuytsH-Index: 55
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The purpose of this work was to evaluate the potential of functional imaging with 18 F-FDG PET, 18 F-fluoromisonidazole PET, diffusion-weighted MRI, and dynamic contrast-enhanced MRI to provide an appropriate and reliable biologic target for dose painting in radiotherapy for head and neck squamous cell carcinoma (HNSCC). Methods: Fifteen patients with locally advanced HNSCC, treated with concomitant chemoradiotherapy, were prospectively enrolled in a bioimaging protocol. Sequential PET ( 18 F-FD...
257 CitationsSource
#1Sungheon Kim (UPenn: University of Pennsylvania)H-Index: 29
#1Sungheon Kim (UPenn: University of Pennsylvania)H-Index: 10
Last. Harish Poptani (UPenn: University of Pennsylvania)H-Index: 47
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Purpose: The aim of this study was to investigate the utility of apparent diffusion coefficient (ADC) for prediction and early detection of treatment response in head and neck squamous cell carcinomas (HNSCC). Experimental Design: Diffusion-weighted magnetic resonance imaging studies were performed on 40 patients with newly diagnosed HNSCC before, during, and after the end of chemoradiation therapy. Analysis was done on data from 33 patients after exclusion of 7 patients that had incomplete data...
380 CitationsSource
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#2Vincent VandecaveyeH-Index: 35
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50 Citations
#1Ferdia A. Gallagher (University of Cambridge)H-Index: 34
#2Mikko I. Kettunen (University of Cambridge)H-Index: 53
Last. Kevin M. Brindle (University of Cambridge)H-Index: 80
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As alterations in tissue pH underlie many pathological processes, the capability to image tissue pH in the clinic could offer new ways of detecting disease and response to treatment. Dynamic nuclear polarization is an emerging technique for substantially increasing the sensitivity of magnetic resonance imaging experiments. Here we show that tissue pH can be imaged in vivo from the ratio of the signal intensities of hyperpolarized bicarbonate (H(13)CO(3)(-)) and (13)CO(2) following intravenous in...
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The identification of robust prognostic and predictive biomarkers would transform the ability to implement an individualised approach to radiotherapy. In this regard, there has been a surge of interest in the use of functional imaging to assess key underlying biological processes within tumours and their response to therapy. Importantly, functional imaging biomarkers hold the potential to evaluate tumour heterogeneity/biology both spatially and temporally. An ever-increasing range of functional ...
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Noninvasive imaging biomarkers readily assessed with PET/CT or MR imaging provide functional data that are absent from conventional anatomic imaging and that can be used to guide tailored treatment approaches in patients with squamous cell carcinomas of the head and neck.
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#1Robin PrestwichH-Index: 28
#2Jonathan R SykesH-Index: 19
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Abstract Defining the target for head and neck radiotherapy is a critical issue with the introduction of steep dose gradients associated with intensity-modulated radiotherapy. Tumour delineation inaccuracies are a major source of error in radiotherapy planning. The integration of 18-fluoride fluorodeoxyglucose positron emission tomography ( 18 FDG-PET) and magnetic resonance imaging directly into the radiotherapy planning process has the potential to greatly improve target identification/selecti...
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Defining the target for head and neck radiotherapy is a critical issue with the introduction of steep dose gradients associated with intensity-modulated radiotherapy. Tumour delineation inaccuracies are a major source of error in radiotherapy planning. The integration of 18-fluoride fluorodeoxyglucose positron emission tomography ( 18 FDG-PET) and magnetic resonance imaging directly into the radiotherapy planning process has the potential to greatly improve target identification/selection and de...
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