Transforming growth factor‐β1 requiresNADPHoxidase 4 for angiogenesisin vitroandin vivo

Angiogenesis, the formation of new blood vessels, is a key physiological event in organ development and tissue responses to hypoxia but is also involved in pathophysiologies such as tumour growth and retinopathies. Understanding the molecular mechanisms involved is important to design strategies for therapeutic intervention. One important regulator of angiogenesis is transforming growth factor‐β1 ( TGF ‐β1). In addition, reactive oxygen species...