Metabolism and disposition of [(14)C]tivantinib after oral administration to humans, dogs and rats.

Volume: 44, Issue: 11, Pages: 996 - 1008
Published: Oct 7, 2014
Abstract
1. The biotransformation and disposition of tivantinib in humans, dogs and rats was examined after a single oral administration of [(14)C]tivantinib. Tivantinib constituted no more than one-third of the plasma radioactivity in all species, demonstrating significant contribution of the metabolites to plasma radioactivity. The major circulating metabolites in all species were M4 and M5, hydroxylated metabolites at the benzyl position of the...
Paper Details
Title
Metabolism and disposition of [(14)C]tivantinib after oral administration to humans, dogs and rats.
Published Date
Oct 7, 2014
Volume
44
Issue
11
Pages
996 - 1008
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