A novel role for the Rho-associated kinase, ROCK, in IL-1-stimulated intestinal epithelial cell responses
Abstract
Intestinal epithelial cells (IEC) play a role in mucosal inflammation by producing pro-inflammatory chemokines that may initiate or amplify local responses. IL-1 is a potent activator of IEC and its receptor localizes to focal adhesions. Since the Rho-associated kinase, ROCK, also localizes to focal adhesions, we examined the role of ROCK in IL-1-induced chemokine responses in IEC cell lines. Suppressing ROCK with the Y27632 inhibitor suppressed...
Paper Details
Title
A novel role for the Rho-associated kinase, ROCK, in IL-1-stimulated intestinal epithelial cell responses
Published Date
Dec 1, 2012
Journal
Volume
280
Issue
2
Pages
148 - 155
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