Application of the extended Hildebrand solubility parameter treatment for optimizing reversed-phase high-performance liquid chromatography determination of pharmaceuticals

Retention in HPLC is described in terms of Hildebrand solubility parameters. A set of solvents commonly used in reversed-phase HPLC was classified into selectivity groups by using the extended Hildebrand solubility parameters as descriptors. Optimization rules according to this system are given for improving the selectivity of...