Microtubules as a target for anticancer drugs
Abstract
Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids, were previously considered to work primarily by increasing or decreasing the cellular microtubule mass. Although these effects might have a role in their chemotherapeutic actions, we now know that at lower concentrations, microtubule-targeted drugs can suppress microtubule...
Paper Details
Title
Microtubules as a target for anticancer drugs
Published Date
Apr 1, 2004
Journal
Volume
4
Issue
4
Pages
253 - 265
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