Predicting the Probability of Deferred Radical Treatment for Localised Prostate Cancer Managed by Active Surveillance

Outcome data from a prospective study of active surveillance of localised prostate cancer were analysed to identify factors, present at the time of diagnosis, that predict subsequent radical treatment. Eligible patients had clinical stage T1–T2a, N0–Nx, M0–Mx adenocarcinoma of the prostate with serum PSA < 15 ng/ml, Gleason score ≤ 7, primary Gleason grade ≤ 3, and % positive biopsy cores (pbc) ≤ 50%. Monitoring included serial PSA measurement...