Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

Published on Oct 14, 2010in Nature42.778
· DOI :10.1038/NATURE09413
Faraaz B. Chekeni5
Estimated H-index: 5
(UVA: University of Virginia),
Michael R. Elliott51
Estimated H-index: 51
(UVA: University of Virginia)
+ 10 AuthorsKodi S. Ravichandran66
Estimated H-index: 66
(UVA: University of Virginia)
Sources
Abstract
Apoptotic cells discharge ATP and UTP, which act as 'find-me' signals for phagocytes that in turn engulf dying cells before potentially harmful cellular contents are released. These authors show that the release of ATP and UTP is exclusively by means of the plasma membrane channel pannexin 1, which is opened specifically by caspase activity.
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