Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Abstract
Apoptotic cells release 'find-me' signals at the earliest stages of death to recruit phagocytes. The nucleotides ATP and UTP represent one class of find-me signals, but their mechanism of release is not known. Here, we identify the plasma membrane channel pannexin 1 (PANX1) as a mediator of find-me signal/nucleotide release from apoptotic cells. Pharmacological inhibition and siRNA-mediated knockdown of PANX1 led to decreased nucleotide release...
Paper Details
Title
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Published Date
Oct 1, 2010
Journal
Volume
467
Issue
7317
Pages
863 - 867
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